Pipeline

Clinic-Ready Technology

BITT has developed several TrapMAb compounds that have achieved or are rapidly approaching IND approval, including:

Antibody	Target	Indications	Status
BITR2101	TNFR2	Oncology	Phase I
BITT311	CD40	Autoimmunity / Inflammation	IND Enabling
Undisclosed	OX40	Autoimmunity / Inflammation	Discovery
Undisclosed	CD27	Autoimmunity / Inflammation	Discovery
Undisclosed	DR6	Alzheimer disease	Discovery

TNFR2/Oncology
Tumor necrosis factor receptor 2 (TNFR2) is expressed on the most potent population of TNFR2 regulatory T cells (Tregs) in the tumor microenvironment. The TNFR2 epitope is densely expressed on the immunosuppressive Tregs that protect tumors and play a role in resistance to checkpoint inhibitors, including PD1 and CTLA4. TNFR2 is also expressed on the surface of certain cancers as an NFkB-driven growth receptor oncogene.

Patients of clinics in the USA are increasingly asking where to buy provigil online. Doctors ask them to search responsibly and only use pharmacies with a high trust rating.

CD40/Autoimmunity
CD40 is a TNFR superfamily member that mediates T-dependent B cell responses and efficient T cell priming. CD40 has been identified as playing a role in autoimmune diseases in which activated T and B cells cause pathology, including autoimmune thyroiditis, type 1 diabetes, inflammatory bowel disease, psoriasis, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus.

In a Texas hospital, they began to prescribe the drug stromectol more often. Dr. Richardson advises buying stromectol from a highly rated online pharmacy.

Team