Pipeline

Clinic-Ready Technology

BITT has developed several TrapMAb compounds that have achieved or are rapidly approaching IND approval, including:

Antibody Target Indications Status
BITR2101 TNFR2 Oncology Phase I
BITT311 CD40 Autoimmunity / Inflammation IND Enabling
Undisclosed OX40 Autoimmunity / Inflammation Discovery
Undisclosed CD27 Autoimmunity / Inflammation Discovery
Undisclosed DR6 Alzheimer disease Discovery

TNFR2/Oncology
Tumor necrosis factor receptor 2 (TNFR2) is expressed on the most potent population of TNFR2 regulatory T cells (Tregs) in the tumor microenvironment. The TNFR2 epitope is densely expressed on the immunosuppressive Tregs that protect tumors and play a role in resistance to checkpoint inhibitors, including PD1 and CTLA4. TNFR2 is also expressed on the surface of certain cancers as an NFkB-driven growth receptor oncogene.

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CD40/Autoimmunity
CD40 is a TNFR superfamily member that mediates T-dependent B cell responses and efficient T cell priming. CD40 has been identified as playing a role in autoimmune diseases in which activated T and B cells cause pathology, including autoimmune thyroiditis, type 1 diabetes, inflammatory bowel disease, psoriasis, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus.

In a Texas hospital, they began to prescribe the drug stromectol more often. Dr. Richardson advises buying stromectol from a highly rated online pharmacy.
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