Press Releases

In The News

Publications on TNF Superfamily Antagonism

November 2022
TNFR2 antagonistic antibody induces the death of tumor infiltrating
CD4+ Foxp3+ regulatory T cells | Cellular Oncology

June 2022
The Roles of TNFR2 Signaling in Cancer Cells and the Tumor Microenvironment and the Potency of TNFR2 Targeted Therapy | Cells

January 13, 2022
Signal Amplification in Highly Ordered Networks Is Driven by Geometry | Cells

November 2021
A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer | International Immunopharmacology

March 2, 2021
Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions | Nature Communications

February 22, 2021
A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells | Cancer Research (

December 2020
Accumulation of TNFR2-expressing regulatory T cells in malignant pleural effusion of lung cancer patients is associated with poor prognosis – PubMed (

June 2020
Optimizing TNFR2 antagonism for immunotherapy with tumor microenvironment specificity – PubMed (

May 24, 2020
TNFR2 blockade alone or in combination with PD‐1 blockade shows therapeutic efficacy in murine cancer models – Case – 2020 – Journal of Leukocyte Biology – Wiley Online Library

May 2020
Targeting TNFR2 to overcome acquired adaptive resistance to immune checkpoint blockade | The Journal of Immunology (

March 24, 2020
Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL – PubMed (

August 5, 2019
CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches – PubMed (

May 2019
Targeted killing of TNFR2-expressing tumor cells and T regs by TNFR2 antagonistic antibodies in advanced Sézary syndrome – PubMed (

May 28, 2018
Frontiers | TNF Receptor 2 Makes Tumor Necrosis Factor a Friend of Tumors | Immunology (

January 2, 2018
Structural principles of tumor necrosis factor superfamily signaling | Science Signaling (

January 2, 2018
Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer | Science Signaling (

January 2017
Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs – PubMed (